Assuming mid 2018 completion, the acquisition impact would be slightly negative to Core Operating Income in 2018 and 2019, mainly due to R&D investments.

In particular, our expectations could be affected by, among other things: regulatory actions or delays or government regulation generally, including potential regulatory actions or delays relating to the completion of the potential acquisition described in this release, as well as potential regulatory actions or delays with respect to the development of the products described in this release; the potential that the strategic benefits, synergies or opportunities expected from the proposed acquisition may not be realized or may take longer to realize than expected; the successful integration of AveXis into the Novartis Group subsequent to the closing of the transaction and the timing of such integration; potential adverse reactions to the proposed transaction by customers, suppliers or strategic partners; dependence on key AveXis personnel and customers; the uncertainties inherent in the research and development of new healthcare products, including clinical trial results and additional analysis of existing clinical data; our ability to obtain or maintain proprietary intellectual property protection; safety, quality or manufacturing issues; global trends toward health care cost containment, including government, payor and general public pricing and reimbursement pressures; the particular prescribing preferences of physicians and patients; uncertainties regarding actual or potential legal proceedings, including, among others, potential legal proceedings with respect to the proposed acquisition; and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Die US-Firma AveXis hat eine Gentherapie gegen spinale Muskelatrophie entwickelt, die 2019 auf den Markt kommen soll.

Dieser Artikel wurde ausgedruckt unter der Adresse: www.tagesschau.de/investigativ/ndr-wdr/novartis-zolgensma-101.html, Zolgensma - Wie das teuerste Medikament der Welt entstand. The company had been aware of the problems for as many as two months before the drug’s U.S. approval, the FDA said, and it could face criminal or civil penalties.
In addition to Zolgensma being approved in the U.S., it’s approved in Japan, Europe and Brazil. AveXis also offers state of the art AAV9 gene therapy manufacturing capabilities and valuable R&D capabilities, which in addition to AVXS-101, includes other pipeline products for Rett Syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene. As of 2020, Novartis would expect the acquisition impact to strongly contribute to Core Operating Income and Core EPS accretion driven by a significant increase in sales. With nearly 1 million square feet of gene therapy manufacturing capacity, Novartis Gene Therapies is the world’s largest gene therapy manufacturer. Novartis acquired Avexis last year, paying $8.7 billion for the maker of the rare-disease treatment, which is expected to bring in billions of dollars in sales.

Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise. Der therapeutische Nutzen ist womöglich größer und man muss es nur einmal geben statt immer wieder. Novartis Institutes for BioMedical Research, https://www.novartis.com/investors/event-calendar, https://www.novartis.com/investors/financial-data, http://investors.avexis.com/phoenix.zhtml?c=254285&p=irol-IRHome. About NovartisNovartis provides innovative healthcare solutions that address the evolving needs of patients and societies. Avexis is now Novartis Gene Therapies Novartis Gene Therapies is dedicated to developing and commercializing gene therapies for patients and families devastated by rare and life-threatening neurological genetic diseases.

Novartis enters agreement to acquire AveXis Inc. for USD 8.7 bn to transform care in SMA and expand position as a gene therapy and Neuroscience leader Apr 09, 2018 AveXis lead product candidate, AVXS-101, has potential to be first-ever one-time gene replacement therapy for spinal muscular atrophy (SMA), a disease which results in early death or lifelong disability with considerable … We believe AVXS-101 could create a lifetime of possibilities for the children and families impacted by this devastating condition. The disease often leads to paralysis, breathing difficulty and death within months for babies born with the most serious Type I form.

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