However, previous studies on prenatal exposure to PFASs and allergic disorders in offspring provided inconsistent results. Although studies have shown a decrease in body burdens of PFOA and PFOS after restriction of usage in some countries since the early 2000s (Haug et al. bLog-transformed PFASs as continuous variables. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Because the hypothalamic–pituitary–ovarian axis (HPO) and the hypothalamic–pituitary–thyroid axis (HPT) are physiologically related and act together as a unified system, both hyper- and hypothyroidism may result in menstrual disturbances (Doufas and Mastorakos 2000). INTRODUCTION. Pre-pregnant women with higher levels of log-transformed perfluorooctanate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonate (PFHxS) had increased odds of self-reported history of irregular menstrual cycle [PFOA-adjusted odds ratio (OR)=1.52 (95% CI: 1.08, 2.15); PFOS OR=1.29 (95% CI: 0.98, 1.70); PFNA OR=1.50 (95% CI: 1.03, 2.07); PFHxS OR=1.80 (95% CI: 1.17, 2.77)] and long menstrual cycle [PFOA OR=1.50 (95% CI: 1.06, 2.10); PFOS OR=1.34 (95% CI: 1.02, 1.75); PFNA OR=1.49 (95% CI: 1.05, 2.11); PFHxS OR=1.73 (95% CI: 1.13, 2.65)]. The median age at menarche was 13 y. Our study was actually a prospective cohort study, though the current analysis was cross-sectional in nature. We aimed to examine the association between prenatal exposure to PFASs and childhood atopic dermatitis (AD) in offspring up to 24 months of age. Found inside – Page 368Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr. ... Alternative and legacy perfluoroalkyl substances: differences between European and Chinese river/estuary systems. Bach CC, Bech BH, Brix N, Nohr EA, Bonde JP, Henriksen TB. contact Table 3 presents that most PFASs exposures were positively associated with irregular menstrual cycle, and the associations with PFOA, PFNA, and PFHxS levels were statistically significant. However, other studies observed no association between PFASs and TTP or subfecundity (Bach et al. As such, they contain at least one perfluoroalkyl moiety, -C n F 2n -. 2015; Fei et al. This study was partly funded by the National Basic Science Research Program (Ministry of Science and Technology of China) (2014CB943300), the Shanghai Municipal Commission of Health and Family Planning (GWIII-26) and was supported by Xinhua Hospital Biobank. Conversely, increasing PFOA, PFNA, and PFHxS levels were associated with higher odds of self-reported history of hypomenorrhea in certain categories. PFASs concentrations were treated as a continuous variable (log transformed) as well as categorized into quartiles, with the lowest quartile as the reference level. The corresponding prevalence in our study was 20.1%, 6.7%, and 8.0%, respectively. Environ Res. 2012; Whitworth et al. Fourth, information on menstrual cycle characteristics in the past 12 mo was collected retrospectively. Found inside – Page 82Perfluoroalkyl and Polyfluoroalkyl Substances in the Environment: Terminology, Classification, and Origins. Integrated Environmental Assessment and Management 7(4):513–541. Butt CM, Muir DCG, Mabury SA (2014). If you need assistance accessing journal content, please Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Iñiguez C, Martinez D, Costa O, Santa-Marina L, Pereda-Pereda E, Schettgen T, Sunyer J, Vrijheid M. Environ Int. The per- and polyfluoroalkyl substances analyzed in chick-rearing black-legged kittiwakes (Rissa tridactyla) caught in Kongsfjorden, Svalbard, in 2013 and 2014, divided into perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonates a a The limit of detection was <0.05 ng/mL for all compounds. 2012). "This toxicological profile for perfluoroalkyls was prepared consistent with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA) for the preparation of ... 2014). Risks of long and short cycles were evaluated by multinomial logistic regression model, using normal cycles (defined as cycle length between 21 and 35 d) as the reference. Thus, the various cycle characteristics in our study are similar to those reported in other studies in China. 2009). Article CAS Google Scholar 10. It also spells out abbreviations for common PFAS. Altogether, 10 PFASs were analyzed, including PFOA, PFOS, perfluorononanoic acid (PFNA), PFHxS, perfluorodecanoic acid (PFDeA), perfluoroundecanoic acid (PFUA), perfluorobutane sulfonate (PFBS), perfluorododecanoic acid (PFDoA), perfluoroheptanoic acid (PFHpA), and PFOSA. In the adjusted model, a log-unit increase in PFOA, PFNA, and PFHxS was associated with significantly increased odds of self-reported history of irregular menstrual cycle by 52%, 50%, 80%, respectively [PFOA OR=1.52 (95% CI: 1.08, 2.15); PFNA OR=1.50 (95% CI: 1.03, 2.07); PFHxS OR=1.80 (95% CI: 1.17, 2.77)]. This two-volume set provides a unique collection of research on transformation products, their occurrence, fate and risks in the environment. Table 4 shows that each log-unit increase in PFOA, PFOS, PFNA, and PFHxS exposure was associated with decreased odds of self-reported menorrhagia [PFOA OR=0.37 (95% CI: 0.21, 0.65); PFOS OR=0.57 (95% CI: 0.37, 0.90); PFNA OR=0.47 (95% CI: 0.26, 0.86); PFHxS OR=0.14 (95% CI: 0.06, 0.36)]. Integr Environ Assess Manag 2011, 7:513-41. EHP According to the Organisation for Economic Co-operation and Development (OECD):. Table 4 lists PFASs in the first column; the corresponding n values, crude OR values (95 percent confidence interval), and adjusted OR values (95 percent confidence interval) for menorrhagia and hypomenorrhea are listed in the other columns separately. Several PFAS have been identified as endocrine-disrupting chemicals based on their ability to interfere with normal reproductive function and hormonal signalling. Carbon-isotope labeled internal standards were added each time before extraction. Mounting evidence from animal (Chang et al. Human exposure to per- and polyfluoroalkyl substances (PFAS) is a public health concern that the Centers for Disease Control and Prevention's (CDC) National Center for Environmental Health (NCEH) and the Agency for Toxic Substances and Disease Registry (ATSDR) are helping our local, territorial, tribal, state, and federal partners . Included were couples who were at least 20 y of age, registered residents of Shanghai with no plan to move out of Shanghai in the next 2 y, had stopped using contraception, and planned to conceive naturally and give birth in the collaborating hospitals. The objective of this study was to investigate this association in women who attempted to conceive in China. Following its well-received predecessor, this book offers an essential guide to chemists for understanding fluorine in spectroscopy. Perfluoroalkyl substances (PFASs) are synthetic compounds first developed in the 1940s due to their unique thermal and chemical properties that render them useful in a myriad of consumer products and industrial applications. Literature shows that men have a higher level of PFASs than women. Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are found widespread in drinking water, foods, food packaging materials and other consumer products. This book serves as a comprehensive resource on toxicants that can be released from food packaging materials and household plastics. Second, we excluded women who had difficulties in conception. 2013; Vestergaard et al. A prospective cohort study demonstrated that pregnant women with higher PFHxS levels had elevated TSH levels (Wang et al. 2014). There is evidence that exposure to certain PFAS can have adverse health effects, and the USEPA published Lifetime Health Advisories for two of the most significant perfluoroalkyl acids (PFAAs). Between August 2013 and April 2015, the Shanghai Birth Cohort Study enrolled women who came for the care at two preconception care clinics in Shanghai, China. The toxicity of PFASs has been extensively studied in experimental animals, with developmental toxicity, carcinogenicity, hepatotoxicity, immunotoxicity, and hormonal effects identified as the effects of most concern (Kennedy et al. Int J Environ Res Public Health. Instead, they have a non-fluorine atom (typically hydrogen or oxygen) attached to at least one, but not all, carbon atoms, while at least Disclaimer, National Library of Medicine We aimed to investigate the association between prenatal PFAS exposure and hypertensive disorders of pregnancy (HDP) in humans. The third vortex was performed after adding 150μL acetonitrile of 1% formic acid. 9602(a)) individually or in groups. 1. Owing to few women with short cycles (n=14), no significant association was found between PFASs exposure and short cycles (see Table S4). Site by Bell Media. The following question was used to assess menstrual cycle characteristics “Is your menstrual cycle regular, i.e., variations month by month within 7 d?” If the answer was “No,” then “What were the longest and shortest menstrual cycles in the past year?” Specific numbers of days were recorded. A . PFAS half-life varies by species and between genders in animal studies, due to differences in renal clearance rates. 2012; Whitworth et al. We examined associations of serum PFAS concentrations with longitudinal . This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the ... The other six PFASs were detected in at least 97% of the samples. A Danish National Birth Cohort also linked maternal serum concentrations of PFOS and PFOA with subfecundity (Fei et al. Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Clinical Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Children Gastroenterology and Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Science and Research, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai, China. Many are universally detected in the U.S. (>95% of the population) and worldwide as well as in natural ecosystems (1,2).PFASs have been produced since the late 1940s, and because of their unique properties, including thermal stability, hydrophobicity, and . Women were queried concerning their menstrual cycle characteristics in the past year. Crit Rev Toxicol. 2011; Harlow et al. New Jersey (NJ) residents in some areas may be exposed to perfluoroalkyl and polyfluoroalkyl substances (PFAS) due to PFAS contamination of public drinking water. In rats, PFASs can interfere with the estrous cycle. PFASs are defined as fluorinated substances that contain at least one fully . Material published in Careers. Ohmori K, Kudo N, Katayama K, Kawashima Y 2003. The study includes three major parts:1) Identification of relevant per-and polyfluorinated substances and their use in various industrial sectors in the Nordic market by interviews with major players and database information; 2) Emissions ... Bethesda, MD 20894, Help Per- and polyfluoroalkyl substances (PFASs) are used in products, such as aqueous film-forming foam and fluorochemical surfactants, because of their high chemical stability. Table 3 Associations between PFASs (ng/mL) and irregular and long cycles in preconception women in Shanghai, China, 2013–2015. 2012). Reverse causality was postulated for this phenomenon (Bach et al. Sixteen studies investigated the association between PFAS exposure in men and semen parameters, reproductive hormone levels, or TTP. Pollution threatens the Laurentian Great Lakes and is a serious problem. This book examines what is known about the major classes of persistent toxic organic pollutants.
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