If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as cirrhosis, liver cancer or bile duct obstruction. To learn what your results mean, talk to your health care provider. Pediatric Reference Ranges Can Low Vitamin D Cause Low Alkaline Phosphatase | Fruit ... Diseases & Conditions, encoded search term (Hypophosphatasia (HPP)) and Hypophosphatasia (HPP), Pathologic Findings in Small Cell Bladder Carcinoma, Fast Five Quiz: Myelodysplastic Syndrome Presentation and Diagnosis, Fast Five Quiz: Precision Medicine in Cancer, Therapy for Patients With NonâSmall Cell Lung Cancer in the Absence of Genomic Mutations, First FDA Recognition for Tumor Marker DatabaseÂ, Topol and Gore: An Exclusive Medscape One-on-One, Faster Testing Promised for Secondary ICU Infections, Hair Disorders: Finding the Root of the Problem, The 'Wondrous Map': Charting of the Human Genome, 20 Years Later. Although it is not usually very common, hypophosphatasemia is the indicator of certain organic disorders, such as: Malnutrition and malnutrition. Renal ultrasonography may reveal nephrocalcinosis and, in some cases, kidney stones. Ricardo R Correa Marquez, MD, EsD, FACP, FACE, FAPCR, CMQ, ABDA, FACHT Associate Professor of Medicine, Program Director, Endocrinology, Diabetes and Metabolism Fellowship Program, Director for Diversity in Graduate Medical Education, University of Arizona College of Medicine-Phoenix; Assistant Professor of Medicine, Mayo College of Medicine, Mayo Clinic Arizona; Staff Endocrinologist, Phoenix Veterans Hospital (VAMC) However, the clinical significance and the underlying genetics of low ALP in unselected populations are unclear. Hello. Low Alkaline Alkaline phosphatase low 34 I would like to know what are the causes of high alkaline phosphatase? The soil is treated with toluene to inhibit microbial activity and the buffer solution maintains the reaction pH. Alkaline Phosphatase Vitamin C deficiency/Scurvy. Shapiro JR, Lewiecki EM. Mine is 44. The reference range on my last blood work had the reference range between 40-129. This test checks the health of your liver, Alkaline phosphatase is an enzyme that can build up in your blood if your liver doesn't work right. Doctors often use this test to look for blocked bile ducts. 490.90 I’m worried. Low intake of vitamin B6, folic acid, and vitamin C, along with excess consumption of vitamin D are contributing factors. Alkaline phosphatase is known to be produced by syncytiotrophoblasts in the placenta and its levels are normally increased in pregnancy. This volume presents the latest data on recent achievements in new and emerging technologies for stroke biomarkers and innovations in stroke assessment. [Medline]. Applicable To. Loss of liver energy: Low alkaline phosphatase shows liver is very weak and the minerals are depleted - which is usually due to cadmium and other heavy metal toxicity. J Hum Genet. I know having too much testosterone is bad for your condition, but I don't think extra protein above your meager level will get you into trouble in this regard, particularly if it is vegetable protein Tietz Textbook of Clinical Chemistry and Molecular ... This book presents the various noninvasive inspiratory and expiratory muscle aids and the outcomes of their use in patients with respiratory muscle dysfunction. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases. Mammalian Alkaline Phosphatases: From Biology to ... Because ALP is important for the growth of strong teeth and bones, individ… CURRENT Medical Diagnosis and Treatment 2020 save. Activities of four amidases and alkaline phosphatase were studied in lymphoid cells obtained from the thymuses of rats during the first 21 days of post natal life. [Medline]. But it is mainly in your liver, bone, kidney, and digestive tract. How to Treat Low Alkaline Phosphatase | Livestrong.com Low Bilirubin Levels Infantile hypophosphatasia: transplantation therapy trial using bone fragments and cultured osteoblasts. Lack of Sustained Response to Teriparatide in a Patient with Adult Hypophosphatasia. Low levels of alkaline phosphatase may indicate hypophosphatasia, a rare genetic disease that affects bones and teeth. An alkaline phosphatase level test (ALP test) is a simple test to perform. Alkaline phosphatase (ALKP) is an enzyme that is produced by many cell types. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. I have always felt very sleepy, tired and exhausted. Abnormal levels of ALP can be caused by liver problems and other types of health problems. The 2022 edition of ICD-10-CM R74.8 became effective on October 1, 2021. 2017 May-Aug. 14 (2):230-234. Can low vitamin D cause low alkaline phosphatase? Several studies in patients with chronic kidney disease or normal renal function have shown that high levels of tissue non-specific alkaline phosphatase (ALP) … ALKALINE PHOSPHATASE is an enzyme found in bone and the liver. Check your thyroid hormones, cortisol, and vitamin D and B12 levels. Megadosing vitamin D, low thyroid hormones, anemia, and high cortisol can lower alkaline phosphatase. 1 comment. Zinc is a cofactor of Alkaline phosphatase, which gets displaced by copper in Wilson's disease, a disorder of copper overload, thereby leading to low levels. ALP is made mostly in the liver and in bone with some made in the intestines and kidneys. I get plenty of A.M. sun Wondering what else could be causing the drop ? Bone biopsy is not the standard of care. Alkaline phosphatase is used as a tumor marker. George A Anadiotis, DO Consulting Staff, Department of Pediatric Rehabilitation and Development, Division of Clinical and Biochemical Genetics, Randall Children's Hospital at Legacy Emanuel By replacing ALP, STRENSIQ enables bone mineralization and reduces toxic levels of systemic PPi and pyridoxal 5ʹ-phosphate (PLP) 3 STRENSIQ cleaves Pi from PPi so it can combine with calcium to form hydroxyapatite crystal, which is necessary to make healthy bone 3,10 hide. Low levels of folic acid, vitamin B-6, as well as pernicious anemia resulting from low levels of vitamin B-12, can cause low levels of alkaline phosphatase. J Inherit Metab Dis. J Clin Endocrinol Metab. The pulp chamber also appears to be enlarged. 3,4 In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. The reference range should be appropriate for the age group undergoing testing, and results vary among laboratories. 36:S73-7. Devising lab specific reference ranges for alkaline phosphatase … Do you have to do additional studies? Make control of TSH-T3-T4 and free T4. What Causes Elevated Alkaline Phosphatase? Pregnancy- The placenta, at the beginning of the third trimester, produces high levels of alkaline phosphatase enzymes. ... Liver Disease- Different forms of liver diseases can change and increase the levels of the alkaline phosphatase. Bone Disease- The bone disease is among the most common causes of elevated alkaline phosphatase. ... More items... J Bone Miner Res. Determine the levels of B vitamins in the blood. It can also result in a number of bone diseases, like osteoporosis. Alkaline phosphate has been low for a few years and they always don’t take it into account, or they say it’s because of age. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs. Among dynamic parameters of bone formation (ie, those that require tetracycline labels to be measurable), mineralizing surface is below the age-specific average of the reference range, whether related to bone surface or osteoid surface. I'm curious about possible causes of low alkaline phosphatase in the blood - I've looked around online and most information I've found is about high levels in the blood, and high levels seem to be more of a concern. It could be hypothyroidism. [Medline]. Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. Thanks. Lifelong Impact. I performed an alkaline phosphatase test and it is low, I have pain in the part of my abdomen, a tachycardia, a lot of reluctance, and I have a high lipid profile and higher triglycerides. This book concludes with a review of each of these topics to expand the mandatory monthly surveillance performed by dialysis centers for each patient who receives home peritoneal dialysis therapy. Alkaline phosphatase (ALP) is an enzyme that is important for a range of bodily processes. Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug ReferenceDisclosure: Nothing to disclose. Hypophosphatemia decreases 2,3-bisphosphoglycerate (2,3-BPG) causing a left shift in the oxyhemoglobin curve. ALP is made mostly in the liver and in bone with some made in the intestines and kidneys. But if your Alkaline phosphatase is lesser or greater than the above values, then there may be some problem in your body. Blood transfusion causes transient decreases in ALP, due to chelation of cations by citrate. Anemia and elevation of the erythrocyte sedimentation rate and C-reactive protein are common. Although it is considered a “liver enzyme,” it is mostly made by the liver and bones. With coverage of the latest therapies, preventions, and imaging studies, along with access to the fully searchable text online at www.expertconsult.com, this comprehensive resource is ideal for any physician who diagnoses, treats, and ... Unique "visual index" at the beginning of the book references the exact chapter and specific page needed for in-depth diagnostic guidance. Superb, high-quality, full-color images illustrate pathognomonic features and common variations. Pseudofractures are one of the hallmarks of hypophosphatasia in adults, often occurring in the lateral aspect of the proximal femur. Is there a connection? share. This is the American ICD-10-CM version of R74.8 - other international versions of ICD-10 R74.8 may differ. George A Anadiotis, DO is a member of the following medical societies: American Medical Association, American Society of Human GeneticsDisclosure: Nothing to disclose. A study examined causes for low serum alkaline phosphatase (ALP) activity in a large Veterans Medical Center were reviewed. Alkaline Phosphatase (ALP) Optimal Result: 39 - 117 U/L, or 39.00 - 117.00 IU/L. You will now enjoy an online version making utility of this book even greater. UPDATED! Anyone have experience with low alkaline phosphatase? A year ago we discovered my high TSH confirming hypothyroidism that had already affected me with symptoms. Malnutrition with low protein assimilation (including low stomach acid production/hypochlorhydria). phosphate level throughout the three weeks of ethanol administration. Is a blood level alkaline phosphatase of 46(range 45 - 129) normal or low? Principles of Bone Biology. Bone biopsy findings include structural parameters (bone volume per tissue volume, trabecular number, trabecular thickness) that are close to the age-specific average of the reference range findings. Gagnon C, Sims NA, Mumm S, et al. ALP : Alkaline phosphatase in serum consists of 4 structural genotypes: the liver-bone-kidney type, the intestinal type, the placental type, and the variant from the germ cells. How to perform and interpret multivariable analysis, using plain language rather than complex derivations. Background: Low serum levels of alkaline phosphatase (ALP) are a hallmark of hypophosphatasia. Identification of children presenting with non-specific clinical features and who have more than one reading of low alkaline phosphatase could help diagnose children with hypophosphatasia. Medscape Education. 1 doctor answer • 1 doctor weighed in. The incisors tend to be the most affected. My 16 year old granddaughter has an alkaline phosphatase value of 120 IU / ml. The rest of the serum values are normal. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. If your Alkaline phosphatase is in between 30 U/L and 120 U/L, then you need not worry as 30-120 U/L is the normal range for men and women. hello, my name is toni, and I take an analytical, phosphatase 37 U / l reference values 38-126u / l I am 44 years old my parents both died of stomach cancer, the digestive prescribed acfol 5mg. But I have observed that I have alkaline phosphatase at 37 when the reference values are between 45-129. A strap is tied up around your upper arm. Everything came back normal except my dr said my alkaline phosphate levels were border line and we should redo the test in two months. How to Plant Broad Beans: Sowing According to the Lunar Calendar, https://www.mundodeportivo.com/futbol/eibar, 3 Exercises to Strengthen Your Knees and Avoid Injuries. Parathyroid hormone treatment improves pain and fracture healing in adult hypophosphatasia. Robison R. The significance of phosphoric esters in metabolism. Medicines to increase Alkaline Phosphatase. http://www.medscape.com/resource/genomic-medicine, You are being redirected to Consuming a poor diet can cause alkaline phosphatase levels to drop. If the alkaline phosphatase (ALP) is high and the GGT is in normal range it suggests a bone disorder. 2010. Berkseth KE, Tebben PJ, Drake MT, Hefferan TE, Jewison DE, Wermers RA. Good morning, my question is the following …Can a patient with low alkaline phosphatase not have anemia?Thank you for helping me with your answer. Histologic examination of the teeth reveals a decrease in cementum, which varies with the severity of the disease. Fun! Moderately high levels of alkaline phosphatase may indicate conditions such as Hodgkin lymphoma, heart failure, or a bacterial infection. Normal value of ALP is 45 to 115 U/L. Bishop N. Clinical management of hypophosphatasia. Providing a comprehensive update, this book is a useful clinical resource for paediatricians and specialists in endocrinology, metabolic bone disease, nephrology, rheumatology, radiology, orthopaedics and clinical genetics who may be faced ... This thread is archived. [Guideline] Jenny C. Evaluating infants and young children with multiple fractures. It is normally elevated during periods of bone growth including childhood/puberty and pregnancy. Pediatrics. My alkaline phosphatase level is 39IU / L. Should I worry or what should I do? What are the risks of having low alkaline phosphatase and low AST levels? Albumin and total protein. Clin Cases Miner Bone Metab. Explanation of test results: A high alk phos level does not reflect liver damage or inflammation. Perform a radiologic skeletal survey on patients in whom the diagnosis of hypophosphatasia is being considered. James Bowman, MD Senior Scholar of Maclean Center for Clinical Medical Ethics, Professor Emeritus, Department of Pathology, University of Chicago Deficient skeletal mineralization is also evident in surviving infants, although it tends to be less severe than in the lethal perinatal cases. No reference ranges exist for pregnancy - levels will be dependent on size of the placenta. High levels of ALP in the blood may indicate bone or liver abnormalities. Alkaline phosphatase (ALP) is one kind enzyme found in your body. report. 31,33. Your Alkaline phosphatase level of 30 indicates a Normal Alkaline phosphatase level. Vitamin C deficiency/Scurvy. Some good options include milk thistle, NAC, taurine, B vitamins, and vitamin C. Additionally, get enough sun, exercise, omega-3 fatty acids, and coffee. [Medline]. They are often elevated, not below normal, as they increase with growth and puberty. It could be hypothyroidism. Also, the decrease that you see might not be significant, but you can mention it to his doctor. It can also result in a number of bone diseases, like osteoporosis. 2001 Numerous tables, graphs, and figures add further clarity to the text." ...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. In lethal cases, there is frequently a near absence of skeletal mineralization. Horacio B Plotkin, MD, FAAP is a member of the following medical societies: American Academy of PediatricsDisclosure: Received salary from PPD, Inc for: PPD. Marlen can be a condition in your digestive-intestinal system (Crohn’s disease), food is not well absorbed and your body takes it from your bones, I am a Parbiomagnetic magnet therapist. It may be a consequence of a low-protein diet or a zinc deficiency. Due to its focus on critical appraisals and recommendations, this book is of interest not only for the researcher who wants to keep up to date, but also for the clinician faced with premature infants in his practice. Make control of TSH-T3-T4 and free T4. 82% Upvoted. [Medline]. Luis O Rohena, MD, MS, FAAP, FACMG Chief, Medical Genetics, San Antonio Military Medical Center; Associate Professor of Pediatrics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine; Associate Professor of Pediatrics, University of Texas Health Science Center at San Antonio 1957 May. Alkaline phosphatase levels are frequently high in patients with metastatic colon cancer. In children with these disorders, their alkaline phosphatase levels are lower than the normal range . One should increase the intake of foods rich in vitamin D and copper. 2015 May-Aug. 12 (2):170-3. Causes of Low Alkaline Phosphatase. Scurvy, caused by insufficient intake of vitamin C, also reduces levels of alkaline phosphatase. Bone formation rate per bone surface is below average. Alkaline phosphate levels in dogs are usually better described as the liver enzymes found in your dog’s liver that are necessary for proper blood work in the body. Liver function test results tend to be normal. The initial alkaline phosphatase level was higher in the sarcoidosis and hepatitis C groups than in the other groups. J Clin Invest. This is not found in other types of rickets. Make control of TSH-T3-T4 and free T4. Folic acid deficiency. You may need this test if you're at risk for a condition that affects your liver. I performed an alkaline phosphatase test and it is low, I have pain in the part of my abdomen, a tachycardia, a lot of reluctance, and I have a high lipid profile and higher triglycerides. Broccoli. Alkaline phosphatase levels rise with the increased bone activity. Representing a new paradigm for the nutrition community, Dietary Reference Intakes encompasses: Estimated Average Requirements (EARs). These are used to set Recommended Dietary Allowances. Recommended Dietary Allowances (RDAs). 2017 Jun 1. 127 (6):2148-2158. J Clin Endocrinol Metab. People with this condition have low levels of the enzyme alkaline phosphatase (ALP), which often affects the development of bones and teeth. He was anemic this summer. Each contains clinical data items from the history, physical examination, and laboratory investigations that are generally included in a comprehensive patient evaluation. Annotation copyrighted by Book News, Inc., Portland, OR But alkaline phosphatase also can be found in other organ systems, Lukacs says. Could it cause problems? + Low Acid Food For Dogs Buenas tardes.I have the value of Alkaline Phosphatase 17.Which specialist should I go to or a clinical doctor is enough for me.Thank you. Low alkaline phosphatase levels are observed less frequently than high ones. a pill a day. 2017 Oct. 32 (10):1977-1980. Thank. Hi, I have alkaline phosphatase, they tell me reagent exhausted k to gnifica x fabor. Epub:[Medline]. Hypothyroidism. Because alk phos requires zinc and magnesium as cofactors, low levels in the serum can most obviously be due to low levels of these minerals. Alkaline phosphatase (ALP). I’ve had pain in my right abdominal area for a month, the pain appears when I drink some alcohol. Liver function tests are blood tests used to help diagnose and monitor liver disease or damage. Resident, Fellow, or Student. This book is broadly divided into five sections and 17 chapters, highlighting recent advances in aflatoxin research from epidemiology to molecular genomics and control measures, biocontrol approaches, modern analytical techniques, economic ... Whyte MP. I don’t drink much but I have a history of fatty liver. Symptoms Of Low Alkaline Phosphatase Levels. The liver makes more ALP than the other organs or the bones. Share cases and questions with Physicians on Medscape consult. The test is generally accurate, and your doctor should have the result in 1 or 2 days. Please confirm that you would like to log out of Medscape. Fractures and rachitic changes are often present. Metabolism. Serum lipids, LPS, IL-1β and TNF-α quantification was also performed prior to termination of the experiment. 2012 Mar 8. Show Graphics (0) Close. Folic acid deficiency. Malnutrition. 2011. Vol 2: 1573-98. Pathologies related to low levels of alkaline phosphatase. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” ... Has been for months. Alkaline Phosphatase is found in all body tissues, but the most important sites are bone and liver. Most levels were good; the only two that stood out were Vitamin D (17.8 ng/mL; that's deficient) and alkaline phosphatase (37 IU/L; that's below the target range, but not by a lot). This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. Premature cranial synostosis often occurs despite an open fontanelle. Other causes of low alkaline phosphatase levels are zinc deficiency, pernicious anemia, hypothyroidism, and congenital hypophosphatasia. Ricardo R Correa Marquez, MD, EsD, FACP, FACE, FAPCR, CMQ, ABDA, FACHT is a member of the following medical societies: Academy of Physicians in Clinical Research, American Association of Clinical Endocrinologists, American College of Endocrinology, American College of Healthcare Trustees, American College of Physicians, American Medical Association, American Thyroid Association, Association of Program Directors in Endocrinology, Endocrine Society, National Hispanic Medical Association, World Medical AssociationDisclosure: Nothing to disclose. It is caused by a mutation in the gene that produces ALP, according to Genetics Home Reference 3. Alkaline phosphatase is an enzyme found throughout your body. Alkaline phosphatase plays a role in the digestion and absorption of fats in the intestinal tract, and some types of oils have been found to directly stimulate alkaline phosphate production 3.In particular, one study published in the journal "Digestive Diseases and Sciences" in 2007 found that animals fed cod liver oil, coconut oil and corn oil had higher alkaline phosphate levels than normal. Alkaline phosphatase is an enzyme produced by either the liver or the bones. Wiley-VCH; 2006. Malnutrition with low protein assimilation (including low stomach acid production/hypochlorhydria). This book aims to raise awareness of IgG4-related sclerosing cholangitis among practicing physicians and to equip readers with a sound understanding of the principles of diagnosis and treatment. Low phosphorus levels (hypophosphatasia) Celiac disease. Schalin-Jäntti C, Mornet E, Lamminen A, Välimäki MJ. Blood levels increase when bones are growing; thus children have higher levels than adults do. You may need this test if you're at risk for a condition that affects your liver. I have 26 of alkaline phosphatase and 85 of platelets, I feel all the time tired, exhausted, with some difficulty breathing, I am 56 years old and I have always felt fatigued, with headaches and dizziness, I do not know what it is to live without these symptom. The 2 patients with hepatitis C had higher AST levels than the patients in the other groups. Laboratory evaluations should include levels of calcium, phosphorus, magnesium, alkaline phosphatase, creatinine, parathyroid hormone (PTH), 25(OH) vitamin D, and 1,25(OH)2 vitamin D. Levels of PLP, PPi in plasma, and PEA in urine determine the diagnosis. It also is made by the placenta of a pregnant woman. That's not much tho, is it? You would normally expect the ALP numbers to be within range or going the other way in an adolescent Mehita. Mineralization lag time is markedly elevated. Do not use ethylenediaminetetraacetic acid (EDTA) tubes because these cause erroneous test results. Thank you so much, if you wanted to know what high alkaline phosphatase means about 461. Activity of acid phosphatase is measured when pH of the buffer is in the acidic range (pH 6.5 is commonly used). Estimation of Serum Alkaline Phosphatase Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial. Whenever possible, measure alkaline phosphatase activity and vitamin B6 levels in all members of the direct family. If anemia is present, iron or a blood transfusion are considerations. [Medline]. It only requires a blood sample. A rise in the level can show that there could be a problem in either of these places. How is the test done? Low alkaline phosphatase levels can lead to a number of problems in your body. [Medline]. Probable bile duct obstruction (choledocholithiasis) requires supplementation with complete PFH. Radiography findings are normal for patients with odontohypophosphatasia, except for osteopenic appearance of the maxilla. Your low alkaline phosphatase level would seem to reinforce the danger you are subjecting yourself too with such a relatively low protein intake. Genetic screening of family members is warranted if vitamin B6 levels are high or alkaline phosphatase levels low. 2 doctor answers • 2 doctors weighed in. High levels of Alkaline phosphatase can be an indicator of blockage in the liver, or damage to bone. [Medline]. Hi everyone! J Clin Endocrinol Metab. Adults. Keywords: Alcohol, alkaline phosphatase, calcium, duration of ethanol, phosphate 1. [Medline]. The starting dose of thyroxine was very low, my symptoms continued even though the TSH test was normal. Broccoli. Aug 2007. Question: Hi I just had a yearly physical with the usual blood work. The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. Found inside – Page 683The importance of the study is that it tests whether normal onto- genic processes, in which alkaline phosphatase levels are low, are duplicated in the dedifferentiation subsequent to injury. Histochemical localization of alkaline ... 2015 Oct 12. FC:Fecal collections, Seq:Microbiome sequencing, IAP:Intestinal Alkaline Phosphatase, LFD:Low-fat diet, HFD:High-fat diet. 1932. Clinical spectrum of hypophosphatasia diagnosed in adults. Jan 2007. Okazaki Y, Kitajima H, Mochizuki N, Kitaoka T, Michigami T, Ozono K. Lethal hypophosphatasia successfully treated with enzyme replacement from day 1 after birth. Get the BIG PICTURE of Pathology - and focus on what you really need to know to score high on the course and board exam If you want a streamlined and definitive look at Pathology - one with just the right balance of information to give you ... Osteoid indices (osteoid thickness, osteoid surface per bone surface, osteoid volume per bone volume) are markedly elevated. The reasons are explained in detail in this section. The former is consistently low and the latter consistently elevated. Folic acid deficiency. 2006 Sep. 118(3):1299-303. Chondrocalcinosis may be visible on radiographic imaging. 9) Breast Cancer.
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