To give you just one example of the impact our employee resource groups are having, the Amgen Black Employees Network collaborated with our Oncology team in 2019 to create an award-winning educational website about multiple myeloma focused on African Americans, who have more than double the risk of developing this disease than the general population. Additionally, in 2019, the Amgen Safety Net Foundation provided nearly $1.5 billion of our medicines to uninsured or underinsured patients in the U.S. at no cost-and nearly $7 billion of our medicines since 2008. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Similarly, MVASI™ and KANJINTI™ complement the many innovative cancer medicines in our portfolio. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
08/20/20 ... Amgen Reports Fourth Quarter And Full Year 2019 Financial Results.

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Bispecific T cell engager (BiTE®) technology is a targeted immuno-oncology platform that is designed to engage patients' own T cells to any tumor-specific antigen, activating the cytotoxic potential of T cells to eliminate detectable cancer. In 2019, we also acquired Nuevolution-now Amgen Research Copenhagen-a pioneer and leader in the field of DNA-encoded libraries. Outside the U.S., we recently completed our second donation of biologic medicines to low- and middle-income countries around the world through the humanitarian aid organization Direct Relief. We acquired the global rights to Otezla®, which is approved in more than 50 countries, including Amgen's 10 largest markets. This expansion will continue to accelerate with two major research initiatives launched in 2019. In this news release, management has presented its operating results for the third quarters of 2019 and 2018, in accordance with U.S. Generally Accepted Accounting Principles (GAAP) and on a non-GAAP basis. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. To learn more about Breakaway Challenge, visit AmgenBreakawayChallenge.com. The Breakaway from Cancer® initiative, founded in 2005, aims to increase awareness of important resources available to people affected by cancer – from prevention through survivorship. In collaboration with SomaLogic, a leader in proteomics technology, deCODE has measured the relative levels of about 5,000 different proteins in plasma collected from 37,000 Icelanders whose genomes have been sequenced. About Amgen If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. This is critical in an environment in which healthcare systems around the world are wrestling with how to pay for the quality care that aging populations desire. "Biology and human genetics have been the foundation of Amgen's innovation for the last four decades," said David M. Reese, M.D., executive vice president of Research and Development at Amgen. Not when cancer costs the world more than $1 trillion every year. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. BiTE molecules are designed to engage patients' T cells to tumor-specific antigens, activating the cytotoxic potential of T cells with the goal of eliminating detectable cancer. Cancer is a good example. Provided $1.5 billion of our medicines to uninsured or underinsured patients in the U.S. at no cost through the Amgen Safety Net Foundation. In January 2020, as part of the collaboration, Amgen acquired a 20.5% ownership stake in BeiGene for approximately $2.8 billion, while BeiGene will contribute up to $1.25 billion to advance 20 medicines from Amgen's innovative oncology pipeline.
While we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. Since then, according to the American Cancer Society, the cancer death rate has been steadily declining, falling 27% in aggregate over the past 25 years. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.

For more information about this year's Amgen Tour of California route and team rosters are available at AmgenTourofCalifornia.com. Hobbs G, Wittinghofer A, Der C. Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down. This mutation is found in approximately 13% of non-small cell lung cancers, 3%-5% of colorectal cancers, and 1%-2% of other solid tumors. We further strengthened our product portfolio in 2019 through the $13.4 billion acquisition of Otezla®, the only oral, non-biologic treatment for psoriasis and psoriatic arthritis. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. Not when the five-year survival rate for many common cancers remains below 50%. According to the World Health Organization, one in three women worldwide over the age of 50 will suffer a fracture due to osteoporosis. Instead of trying to tackle difficult drug targets on their own, these molecules can enlist powerful biological mechanisms to get the job done. Do you want to link to this External Site and leave Amgen.com?


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